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Disclosure - License and Collaboration Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2110104 - Disclosure - Acquisition link:presentationLink link:calculationLink link:definitionLink 2411405 - Disclosure - Acquisition - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2112105 - Disclosure - Prepaid Expenses link:presentationLink link:calculationLink link:definitionLink 2313302 - Disclosure - Prepaid Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 2414406 - Disclosure - Prepaid Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 2115106 - Disclosure - Other Non-Current Assets link:presentationLink link:calculationLink link:definitionLink 2316303 - Disclosure - Other Non-Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 2417407 - Disclosure - Other Non-Current Assets - Schedule of Other Non-Current Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 2118107 - 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Disclosure - Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Detail) link:presentationLink link:calculationLink link:definitionLink 2133110 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 2334307 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 2435417 - Disclosure - Stock-based compensation - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2436418 - Disclosure - Stock-based Compensation - Summary of Stock Option Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 2437419 - Disclosure - Stock-based Compensation - Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2438420 - Disclosure - Stock-based Compensation - Summary of Assumptions Used in Black-Scholes Option-Pricing Model for Stock Options Granted to Employees and Non-Employee Directors (Detail) link:presentationLink link:calculationLink link:definitionLink 2139111 - Disclosure - Leased Properties link:presentationLink link:calculationLink link:definitionLink 2340308 - Disclosure - Leased Properties (Tables) link:presentationLink link:calculationLink link:definitionLink 2441421 - Disclosure - Leased Properties - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2442422 - Disclosure - Leased Properties Leased Properties- Future Minimum Lease Payment (Details) link:presentationLink link:calculationLink link:definitionLink 2143112 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2444423 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2145113 - Disclosure - Grant Awards link:presentationLink link:calculationLink link:definitionLink 2446424 - Disclosure - Grant Awards - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2147114 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 2448425 - Disclosure - Subsequent Events - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink